Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Datema Mareen R, Zuidmeer-Jongejan Laurian, Asero Riccardo, Barreales Laura, Belohlavkova Simona, de Blay Frédéric, Bures Peter, Clausen Michael, Dubakiene Ruta, Gislason David, Jedrzejczak-Czechowicz Monika, Kowalski Marek L, Knulst André C, Kralimarkova Tanya, Le Thuy-My, Lovegrove Alison, Marsh Justin, Papadopoulos Nikolaos G, Popov Todor, Del Prado Náyade, Purohit Ashok, Reese Gerald, Reig Isabel, Seneviratne Suranjith L, Sinaniotis Athanasios, Versteeg Serge A, Vieths Stefan, Zwinderman Aeilko H, Mills Clare, Lidholm Jonas, Hoffmann-Sommergruber Karin, Fernández-Rivas Montserrat, Ballmer-Weber Barbara, van Ree Ronald
Аннотация
OBJECTIVE: Establishing a molecular map of hazelnut allergy across Europe.
METHODS: In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP.
RESULTS: Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen.
CONCLUSIONS: In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.