Microbial pathogenesis · 2025
Plasmatic biochemical changes in COVID-19: Relevant markers that reflect patient genotypic predisposal.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ursulino Jeferson S, Tanabe Eloiza L L, Marques Aldilane L X, da Silva Elaine C O, Leal Juliana G C, Pinto Larissa S, Júnior Edmilson R R, Santos Luana K C, Sales-Marques Carolinne, Coelho Jorg A P M, Sales Marcos V S, Fonseca Eduardo J S, Fragoso Thiago S, Barreto Emiliano O, Borbely Alexandre U, Leite Ana C R, Aquino Thiago M
Аннотация
BACKGROUND: The emergence of COVID-19 as a global health threat, particularly exacerbated in pre-existing chronic conditions, underscores the imperative for continuous exploration of biomarkers to enhance clinical management.
METHODS: This study employs multidimensional techniques, analyzing COVID-19 and control blood samples through plasma NMR, Raman spectroscopy, and leukocyte SNP genotyping.
RESULTS: NMR metabolomics identifies heightened levels of L-lactic acid, D-glucose, VLDL/LDL, L-glutamic acid, and 1-methyl-histidine in COVID-19, alongside reduced levels of L-alanine and L-histidine. ROC curves exhibit robust discriminatory power, affirming the model's efficacy in distinguishing COVID-19 from control samples. Raman spectroscopy unveils bands associated with molecular vibrations of amino acids, lipids, and carotenoids in COVID-19. SNP genotyping reveals the rs2070788-TMPRSS2 association with elevated COVID-19 risk and rs8259-CD147 association with protective effects.
CONCLUSIONS: Our findings provides a comprehensive investigation of acute COVID-19, highlighting novel biomarkers, particularly the correlation between 1-methyl-histidine levels and the TMPRSS2 GG + AG genotype.
METHODS: This study employs multidimensional techniques, analyzing COVID-19 and control blood samples through plasma NMR, Raman spectroscopy, and leukocyte SNP genotyping.
RESULTS: NMR metabolomics identifies heightened levels of L-lactic acid, D-glucose, VLDL/LDL, L-glutamic acid, and 1-methyl-histidine in COVID-19, alongside reduced levels of L-alanine and L-histidine. ROC curves exhibit robust discriminatory power, affirming the model's efficacy in distinguishing COVID-19 from control samples. Raman spectroscopy unveils bands associated with molecular vibrations of amino acids, lipids, and carotenoids in COVID-19. SNP genotyping reveals the rs2070788-TMPRSS2 association with elevated COVID-19 risk and rs8259-CD147 association with protective effects.
CONCLUSIONS: Our findings provides a comprehensive investigation of acute COVID-19, highlighting novel biomarkers, particularly the correlation between 1-methyl-histidine levels and the TMPRSS2 GG + AG genotype.