Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
Biologically enhanced anterior cruciate ligament reconstruction: Platelet-rich plasma or bone marrow aspirate concentrate does not lead to better clinical or radiological outcomes-A randomized controlled trial of 175 cases with 2 years of follow-up.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mokhtar Akram Aldawoudy, Gawish Hesham, Abdelgawad Ahmed, Deghady Akram, Hassaan Esraa, Matarawy Khaled, Amer Ahmed, Soliman Eiman, Hirschmann Michael T
Аннотация
PURPOSE: To compare the clinical and radiological outcomes of anterior cruciate ligament reconstruction (ACLR) augmented with platelet-rich plasma (PRP) (1) or bone marrow aspirate concentrate (BMAC) (2) against a control group undergoing standard ACLR without biological additives.
METHODS: One hundred seventy-five patients undergoing biologically enhanced ACLR using semitendinosus quadruple autograft were prospectively included in this randomized controlled trial. Patients were randomized to either the control group (no biological additives, n = 79) or ACLR plus application of PRP to the graft (n = 53) or ACLR plus BMAC application to the graft (n = 43). ACLR techniques were standardized for all patients, and all were performed by a senior surgeon. Biological additives were also standardized and prepared by a senior laboratory physician in the operating room. After an average of 2 years, patients were assessed clinically, and SI of the ACL graft was measured in the magnetic resonance imaging (MRI).
RESULTS: There was no clinically significant difference in clinical outcomes (clinical examination [p = 0.867] and patients' reported outcome scores, Lysholm [p = 0.881], International Knee Documentation Committee [p = 0.864] and Marx activity return to sport scale [p = 0.666]). There was no significant difference in MRI SI of the intra-articular graft or the graft inside the tunnels (p = 0.898) after a mean of 2 years. Cases with BMAC addition to the graft showed poorer MRI SI.
CONCLUSION: Biological ACL reconstruction enhanced with PRP or BMAC did not reveal any statistically significant clinical or radiological results; on the contrary, BMAC application may lead to poorer MRI SI.
LEVEL OF EVIDENCE: Level I, randomized controlled trial.
METHODS: One hundred seventy-five patients undergoing biologically enhanced ACLR using semitendinosus quadruple autograft were prospectively included in this randomized controlled trial. Patients were randomized to either the control group (no biological additives, n = 79) or ACLR plus application of PRP to the graft (n = 53) or ACLR plus BMAC application to the graft (n = 43). ACLR techniques were standardized for all patients, and all were performed by a senior surgeon. Biological additives were also standardized and prepared by a senior laboratory physician in the operating room. After an average of 2 years, patients were assessed clinically, and SI of the ACL graft was measured in the magnetic resonance imaging (MRI).
RESULTS: There was no clinically significant difference in clinical outcomes (clinical examination [p = 0.867] and patients' reported outcome scores, Lysholm [p = 0.881], International Knee Documentation Committee [p = 0.864] and Marx activity return to sport scale [p = 0.666]). There was no significant difference in MRI SI of the intra-articular graft or the graft inside the tunnels (p = 0.898) after a mean of 2 years. Cases with BMAC addition to the graft showed poorer MRI SI.
CONCLUSION: Biological ACL reconstruction enhanced with PRP or BMAC did not reveal any statistically significant clinical or radiological results; on the contrary, BMAC application may lead to poorer MRI SI.
LEVEL OF EVIDENCE: Level I, randomized controlled trial.