Gland surgery · 2026
Mammogram geometric projection localization (MaGPL) for surgical body-surface localization of nonpalpable breast calcifications.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chen Xiangqing, Lin Xin, Liang Bo, Xu Yuhang, Lin Jiali, Zhang Yi, Zhang Yifang, Guo Lijuan, Huang Jinbo, Ding Zhuliang, Huang Renxing, Kong Qiunan, Zhang Fen, Liu Haiming, Chen Yuxia, Zhang Guochun, Wang Yulei
Аннотация
BACKGROUND: Precise surgical excision of nonpalpable breast microcalcifications remains challenging when conventional localization equipment is limited or not routinely available across clinical settings, underscoring the need for an accessible and reproducible alternative approach. This study aimed to assess the feasibility and localization accuracy of a novel mammography-based localization strategy for guiding diagnostic surgical excision of nonpalpable breast microcalcifications.
METHODS: This multicenter retrospective study evaluated a mammography-based geometric localization approach termed mammogram geometric projection localization (MaGPL). The technique applies a boundary-defined, range-based "Maximal Width Crossing Criterion" to reconstruct a body-surface coordinated field from two standard mammographic projections, preferentially the craniocaudal (CC) and lateromedial (LM) views. By deliberately selecting the most geometrically stable boundary information from each projection, MaGPL defines axis-specific localization boundaries, forming the geometric basis for boundary-defined localization of nonpalpable calcifications. A total of 41 patients (45 lesions) underwent diagnostic excision guided by MaGPL. Localization accuracy was evaluated using the geometric offset (D offset ), defined as the linear distance between the radiographic center of the calcification cluster and the center of the excised specimen measured on intraoperative mammography.
RESULTS: The cohort had a median age of 48 years (range, 25-81 years) and a mean mammographically estimated breast volume of 370±158 mL. The mean linear extent of the target calcification clusters was 22.6±15.1 mm (range, 3.0-67.0 mm), and pathologic examination confirmed malignancy in 18 of 45 lesions (40.0%). All calcification clusters were successfully excised in a single operation, achieving a 100% intraoperative retrieval rate. The median D offset was 9.7 mm [interquartile range (IQR), 8.3-13.0 mm], indicating a clinically acceptable level of geometric localization precision. Orthogonal CC + LM projections yielded smaller offsets than non-orthogonal combinations (P=0.003). Larger breast volumes were associated with greater D offset (P<0.001), whereas breast density and calcification extent or location showed no significant association.
CONCLUSIONS: MaGPL represents a standardized, equipment-independent alternative for body-surface localization to guide surgical excision of nonpalpable breast microcalcifications, offering reproducible and clinically applicable localization accuracy without additional cost, with particular utility in community and resource-limited settings.
METHODS: This multicenter retrospective study evaluated a mammography-based geometric localization approach termed mammogram geometric projection localization (MaGPL). The technique applies a boundary-defined, range-based "Maximal Width Crossing Criterion" to reconstruct a body-surface coordinated field from two standard mammographic projections, preferentially the craniocaudal (CC) and lateromedial (LM) views. By deliberately selecting the most geometrically stable boundary information from each projection, MaGPL defines axis-specific localization boundaries, forming the geometric basis for boundary-defined localization of nonpalpable calcifications. A total of 41 patients (45 lesions) underwent diagnostic excision guided by MaGPL. Localization accuracy was evaluated using the geometric offset (D offset ), defined as the linear distance between the radiographic center of the calcification cluster and the center of the excised specimen measured on intraoperative mammography.
RESULTS: The cohort had a median age of 48 years (range, 25-81 years) and a mean mammographically estimated breast volume of 370±158 mL. The mean linear extent of the target calcification clusters was 22.6±15.1 mm (range, 3.0-67.0 mm), and pathologic examination confirmed malignancy in 18 of 45 lesions (40.0%). All calcification clusters were successfully excised in a single operation, achieving a 100% intraoperative retrieval rate. The median D offset was 9.7 mm [interquartile range (IQR), 8.3-13.0 mm], indicating a clinically acceptable level of geometric localization precision. Orthogonal CC + LM projections yielded smaller offsets than non-orthogonal combinations (P=0.003). Larger breast volumes were associated with greater D offset (P<0.001), whereas breast density and calcification extent or location showed no significant association.
CONCLUSIONS: MaGPL represents a standardized, equipment-independent alternative for body-surface localization to guide surgical excision of nonpalpable breast microcalcifications, offering reproducible and clinically applicable localization accuracy without additional cost, with particular utility in community and resource-limited settings.