Neuroimmunomodulation · 2004
Splenic denervation suppresses mRNA gene expression and protein production of IL-1beta and IL-6 by peritoneal macrophages in both Trypanosoma brucei brucei-infected and non-infected rats.
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Liu Yajuan, Li Zhilun, Svarén-Quiding Cecilia, Cui Jianguo, Ozenci Volkan, Bakhiet Moiz
Аннотация
OBJECTIVE: To test the hypothesis that the nervous system participates in modulating the immune response during experimental African trypanosomiasis caused by Trypanosoma brucei brucei.
METHODS AND RESULTS: Using in situ hybridization and immunochemistry, we studied the effects of splenic sympathectomy on mRNA gene expression and protein production of IL-1beta and IL-6 in splenic and peritoneal macrophages (PMPhi) of Sprague-Dawley rats infected with T. brucei brucei and non-infected rats. The enhancements of mRNA gene expression and production of IL-1beta and IL-6 by peritoneal macrophages were significantly suppressed by the splenic sympathectomy in both infected and non-infected rats.
CONCLUSIONS: Our data indicate a probably stimulatory role of the sympathetic nervous system during the host immune response in both normal and T. brucei brucei-infected rats.
METHODS AND RESULTS: Using in situ hybridization and immunochemistry, we studied the effects of splenic sympathectomy on mRNA gene expression and protein production of IL-1beta and IL-6 in splenic and peritoneal macrophages (PMPhi) of Sprague-Dawley rats infected with T. brucei brucei and non-infected rats. The enhancements of mRNA gene expression and production of IL-1beta and IL-6 by peritoneal macrophages were significantly suppressed by the splenic sympathectomy in both infected and non-infected rats.
CONCLUSIONS: Our data indicate a probably stimulatory role of the sympathetic nervous system during the host immune response in both normal and T. brucei brucei-infected rats.
Предметные рубрики MeSH
AnimalsDenervationDisease Models, AnimalGene Expression RegulationInterleukin-1Interleukin-6Macrophages, PeritonealMaleNeuroimmunomodulationPeritoneumRNA, MessengerRatsRats, Sprague-DawleyReaction TimeSpleenSympathetic Fibers, PostganglionicTrypanosoma brucei bruceiTrypanosomiasis, AfricanTyrosine 3-Monooxygenase