The American journal of the medical sciences · 2026
Stress ulcer prophylaxis in mechanically ventilated patients.
СтатьяМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Saeed Aamir, Yousuf Saira, Ali Ijlal Akbar, Chen Anna, Khalid Umar Abdul Rehman, Noverati Nicholas, Hasnan Ghulam Ali, Akbar Hina, Qamar Usama, Beran Azizullah, Saleem Nasir, Radlinski Mark, Kamal Faisal
Аннотация
Studies have compared proton pump inhibitors (PPI) with Histamine 2 receptor antagonists (H2RA) and placebo for upper gastrointestinal bleeding (UGIB) prophylaxis in mechanically ventilated patients. We conducted this meta-analysis to compare PPI with H2RA or placebo for UGIB prophylaxis in these patients. Our outcomes of interest were clinically important UGIB, overall UGIB, mortality, ventilator-associated pneumonia (VAP) and Clostridium difficile infection (CDI). We calculated pooled risk ratio (RR) with 95% confidence intervals (CI) for all outcomes. We included eight RCTs comprising 32,873 patients. Risk of clinically important UGIB was significantly lower in PPI group, RR (95%CI): 0.53 (0.32, 0.89). Risk of overall UGIB was also significantly lower in PPI group. There was no significant difference in mortality, VAP and CDI between groups. This meta-analysis demonstrates the superiority of PPI to H2RA and placebo for prophylaxis of UGIB in mechanically ventilated patients, without increasing the risk of adverse events.