Clinical and experimental hepatology · 2016
Simple non-invasive markers for early diagnosis and determination of the severity of liver diseases.
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Gudowska Monika, Wrona Alicja, Gruszewska Ewa, Panasiuk Anatol, Cylwik Bogdan, Swiderska Magdalena, Filisiak Robert, Szmitkowski Maciej, Chrostek Lech
Аннотация
AIM OF THE STUDY: The aim of the study was to evaluate the effect and severity of liver diseases of different etiologies on the values of three non-invasive fibrosis markers.
MATERIAL AND METHODS: Serum samples from 65 patients with alcoholic cirrhosis, 31 with non-alcoholic cirrhosis and 32 with toxic hepatitis, were tested. Cirrhotic patients were classified according to the Child-Pugh scale. The age-platelet (AP) index, HUI score and Fibro Q index were calculated using the specific formulas.
RESULTS: The values of all tested scores were significantly higher in controls than in patients with liver diseases and were significantly different between liver diseases. The patients with alcoholic and non-alcoholic cirrhosis had higher values of the AP index, HUI score and Fibro Q index than patients with toxic hepatitis. HUI and Fibro Q scores appeared to vary according to the severity of liver damage and were higher in Child-Pugh class C than in classes A and B.
CONCLUSIONS: We conclude that all tested scores based on liver function tests are good markers for non-invasive diagnosis of liver damage. Additionally, HUI and Fibro Q scores reflect the severity of liver cirrhosis.
MATERIAL AND METHODS: Serum samples from 65 patients with alcoholic cirrhosis, 31 with non-alcoholic cirrhosis and 32 with toxic hepatitis, were tested. Cirrhotic patients were classified according to the Child-Pugh scale. The age-platelet (AP) index, HUI score and Fibro Q index were calculated using the specific formulas.
RESULTS: The values of all tested scores were significantly higher in controls than in patients with liver diseases and were significantly different between liver diseases. The patients with alcoholic and non-alcoholic cirrhosis had higher values of the AP index, HUI score and Fibro Q index than patients with toxic hepatitis. HUI and Fibro Q scores appeared to vary according to the severity of liver damage and were higher in Child-Pugh class C than in classes A and B.
CONCLUSIONS: We conclude that all tested scores based on liver function tests are good markers for non-invasive diagnosis of liver damage. Additionally, HUI and Fibro Q scores reflect the severity of liver cirrhosis.