Nature communications · 2025
CSF total tau as a proxy of synaptic degeneration.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Soares Carolina, Bellaver Bruna, Ferreira Pamela C L, Povala Guilherme, Schaffer Aguzzoli Cristiano, Ferrari-Souza João Pedro, Zalzale Hussein, Lussier Firoza Z, Rohden Francieli, Abbas Sarah, Bauer-Negrini Guilherme, Teixeira Leffa Douglas, Benedet Andréa Lessa, Langhough Rebecca, Betthauser Tobey J, Christian Bradley T, Wilson Rachael E, L Tudorascu Dana, Rosa-Neto Pedro, Karikari Thomas K, Zetterberg Henrik, Blennow Kaj, Zimmer Eduardo R, Johnson Sterling C, Pascoal Tharick A
Аннотация
Cerebrospinal fluid (CSF) total tau (t-tau) is considered a biomarker of neuronal degeneration alongside brain atrophy and fluid neurofilament light chain protein (NfL) in biomarker models of Alzheimer's disease (AD). However, previous studies show that CSF t-tau correlates strongly with synaptic dysfunction/degeneration biomarkers like neurogranin (Ng) and synaptosomal-associated protein 25 (SNAP25). Here, we compare the association between CSF t-tau and synaptic degeneration and axonal/neuronal degeneration biomarkers in cognitively unimpaired and impaired groups from two independent cohorts. We observe a stronger correlation between CSF t-tau and synaptic biomarkers than neurodegeneration biomarkers in both groups. Synaptic biomarkers explain a greater proportion of variance in CSF t-tau levels compared to neurodegeneration biomarkers. Notably, CSF t-tau levels are elevated in individuals with abnormalities only in synaptic biomarkers, but not in individuals with abnormalities only in neurodegeneration biomarkers. Our findings suggest that CSF t-tau is a closer proxy for synaptic degeneration than for axonal/neuronal degeneration.