Fertility and sterility · 2019
Effect of body mass index on pregnancy outcomes with the freeze-all strategy in women with polycystic ovarian syndrome.
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Qiu Meiting, Tao Yu, Kuang Yanping, Wang Yun
Аннотация
OBJECTIVE: To investigate the effects of body mass index (BMI) on assisted reproductive outcomes with the freeze-all strategy for patients with polycystic ovary syndrome (PCOS).
DESIGN: Retrospective cohort study.
SETTING: Tertiary care academic medical center.
PATIENT(S): A total of 3,079 women with PCOS across different BMIs at our institution from January 2015 to May 2017 were stratified into cohorts.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Implantation rate, clinical pregnancy rate, early miscarriage rate, and live birth rate.
RESULT(S): The live birth rate was most favorable in underweight (BMI < 18.5 kg/m2) and normal weight cohorts (18.5 ≤ BMI < 25 kg/m2) and progressively decreased as BMI increased. Moreover, the obese cohort (BMI ≥ 30 kg/m2) of patients with PCOS who had frozen ET cycles had a relatively high early miscarriage rate.
CONCLUSION(S): The live birth rates are highest in underweight and normal weight patients with PCOS undergoing IVF with the freeze-all strategy. Furthermore, there is a progressive and statistically significant decrease in the live birth rate and an increase in the miscarriage rate in obese patients with PCOS.
DESIGN: Retrospective cohort study.
SETTING: Tertiary care academic medical center.
PATIENT(S): A total of 3,079 women with PCOS across different BMIs at our institution from January 2015 to May 2017 were stratified into cohorts.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Implantation rate, clinical pregnancy rate, early miscarriage rate, and live birth rate.
RESULT(S): The live birth rate was most favorable in underweight (BMI < 18.5 kg/m2) and normal weight cohorts (18.5 ≤ BMI < 25 kg/m2) and progressively decreased as BMI increased. Moreover, the obese cohort (BMI ≥ 30 kg/m2) of patients with PCOS who had frozen ET cycles had a relatively high early miscarriage rate.
CONCLUSION(S): The live birth rates are highest in underweight and normal weight patients with PCOS undergoing IVF with the freeze-all strategy. Furthermore, there is a progressive and statistically significant decrease in the live birth rate and an increase in the miscarriage rate in obese patients with PCOS.
Предметные рубрики MeSH
Abortion, SpontaneousAdultBody Mass IndexCryopreservationEmbryo ImplantationFemaleFertilityFertilization in VitroHumansInfertility, FemaleLive BirthPregnancy in ObesityOvulation InductionPolycystic Ovary SyndromePregnancyPregnancy RateReproductive Techniques, AssistedRetrospective StudiesRisk FactorsTreatment Outcome