Zhonghua yi xue za zhi · 2015
[Analysis of clinical feature of IgG4 related disease].
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Li Yanming, Wang He, Fang Fang, Zhang Min, Ju Yang, Sun Tieying
Аннотация
OBJECTIVE: To summarize the clinical characteristics of IgG4 related disease.
METHODS: A retrospective analysis of clinical manifestation, radiography and pathological information of patients diagnosed with IgG4 related disease in Beijing Hospital.
RESULTS: Patients recruited in this study were 7 males and 7 females at the average age of (64.3±10.0) years old. Equal or greater than two organs were suffered in 10 patients. In these involved organs, pancreas was the most suffered organ with 10 times, bile duct and salivary gland was suffered 5 times respectively, lung was suffered 4 times and lacrimal gland was suffered 2 times. Laboratory examination of these 14 cases showed that 5 of these cases were with increased level of plasma IgG and all of the cases were with increased level of IgG4, 7 patients were with increased level of eosinophil count and 9 patients in 12 cases were with the increased level of IgE. All of the diagnosed patients were eusemia and 13 of them received the treatment of glucocorticoid. After usage of glucocorticoid, the clinical symptom and radiography findings were at great improvement, and the levels of IgG4 were decreased, but only two cases were down to normal level.
CONCLUSIONS: IgG4 related disease is a kind of disease with various manifestation and multiple organs are commonly suffered. The increase of IgG, IgE levels and eosinophil count could be considered as diagnosis clues.
METHODS: A retrospective analysis of clinical manifestation, radiography and pathological information of patients diagnosed with IgG4 related disease in Beijing Hospital.
RESULTS: Patients recruited in this study were 7 males and 7 females at the average age of (64.3±10.0) years old. Equal or greater than two organs were suffered in 10 patients. In these involved organs, pancreas was the most suffered organ with 10 times, bile duct and salivary gland was suffered 5 times respectively, lung was suffered 4 times and lacrimal gland was suffered 2 times. Laboratory examination of these 14 cases showed that 5 of these cases were with increased level of plasma IgG and all of the cases were with increased level of IgG4, 7 patients were with increased level of eosinophil count and 9 patients in 12 cases were with the increased level of IgE. All of the diagnosed patients were eusemia and 13 of them received the treatment of glucocorticoid. After usage of glucocorticoid, the clinical symptom and radiography findings were at great improvement, and the levels of IgG4 were decreased, but only two cases were down to normal level.
CONCLUSIONS: IgG4 related disease is a kind of disease with various manifestation and multiple organs are commonly suffered. The increase of IgG, IgE levels and eosinophil count could be considered as diagnosis clues.