[The indicators of alteration of functional activity of vessel wall as new diagnostic criteria of development of initial stages of chronic lymphatic leukemia].

The role of endothelium dysfunction in pathogenesis of B-cell mode of chronic lymphatic leukemia is still uncovered. However, detection of disorders of functional activity of vessel wall at early stages of development of this disease permits to widen actual diagnostic criteria of its initiation and thereafter to make more objective diagnostic itself. The study was targeted to establish the role of endothelium dysfunction in pathogenesis of initial stages (0-1 stages according classification Rai K. et al. 1975) of B-cell mode of chronic lymphatic leukemia. The article presents results of clinical laboratory examination of 30 patients with initial stages of B-cell mode of chronic lymphatic leukemia. The content of classic markers of endothelium dysfunction in blood serum were detected using one time solid-phase enzymoimmunoassay at the moment of admission to hospital before initiation of treatment. In patients with chronic lymphatic leukemia blood serum characterized by increasing of level of E-selectin. ICAM-1, endothelin-1, metabolites of nitrogen nitrite, angiotensin II. At the same time, content of protein C decreased at the stage 0-1 of mentioned pathology. Hence, it is recommended to apply determining in blood serum the content of markers of endothelium dysfunction as additional diagnostic criteria of development of paraneoplastic disorders at initial stages of chronic lymphatic leukemia. These markers include molecules of adhesion (E-selectin, ICAM-I), metabolites of nitrogen nitrite, endothelin-1, protein C. angiotensin II and homocysteine.