Current topics in medicinal chemistry · 2024
The Multitarget Action of Vitamins in the Ischemic Stroke.
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Scotti Luciana, da Silva Pablo Rayff, Monteiro Alex France M, de Araújo Rodrigo Santos Aquino, do Nascimento Vanessa Lima, Monteiro Kadja Luana Chagas, de Aquino Thiago Mendonça, Dos Santos Silva Wadja Feitosa, da Silva Junior Edeildo Ferreira, Scotti Marcus T, Mendonça Junior Francisco Jaime Bezerra
Аннотация
A stroke, also known as a cerebral hemorrhage, occurs when there is an interruption in the blood supply to a part of the brain, resulting in damage to brain cells. This issue is one of the leading causes of death in developed countries, currently killing about 5 million people annually. Individuals who survive ischemic stroke often face serious vision problems, paralysis, dementia, and other sequelae. The numerous efforts to prevent and/or treat stroke sequelae seem insufficient, which is concerning given the increasing global elderly population and the well-known association between aging and stroke risk. In this review, we aim to present and discuss the importance of vitamins in stroke prevention and/or incidence. Vitamins from diet or dietary supplements influence the body at various levels; they are a relevant factor but are reported only in isolated articles. This review reports and updates the multitarget role of vitamins involved in reducing stroke risk.