The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Makkar Steve R, Lipnicki Darren M, Crawford John D, Kochan Nicole A, Castro-Costa Erico, Lima-Costa Maria Fernanda, Diniz Breno Satler, Brayne Carol, Stephan Blossom, Matthews Fiona, Llibre-Rodriguez Juan J, Llibre-Guerra Jorge J, Valhuerdi-Cepero Adolfo J, Lipton Richard B, Katz Mindy J, Wang Cuiling, Ritchie Karen, Carles Sophie, Carriere Isabelle, Scarmeas Nikolaos, Yannakoulia Mary, Kosmidis Mary, Lam Linda, Chan Wai Chi, Fung Ada, Guaita Antonio, Vaccaro Roberta, Davin Annalisa, Kim Ki Woong, Han Ji Won, Suh Seung Wan, Riedel-Heller Steffi G, Roehr Susanne, Pabst Alexander, Ganguli Mary, Hughes Tiffany F, Snitz Beth, Anstey Kaarin J, Cherbuin Nicolas, Easteal Simon, Haan Mary N, Aiello Allison E, Dang Kristina, Pin Ng Tze, Gao Qi, Zin Nyunt Ma Shwe, Brodaty Henry, Trollor Julian N, Leung Yvonne, Lo Jessica W, Sachdev Perminder
Аннотация
We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54-103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging between 1.2 and 10.7 years. Two-step individual participant data meta-analysis was used to pool results of study-wise analyses predicting memory and general cognitive decline from carriage of one or two APOE*4 alleles, and moderation of these associations by age, sex, vascular risk factors, and ethnicity. Separate pooled estimates were calculated in both men and women who were younger (ie, 62 years) and older (ie, 80 years) at baseline. Results showed that APOE*4 carriage was related to faster general cognitive decline in women, and faster memory decline in men. A stronger dose-dependent effect was observed in older men, with faster general cognitive and memory decline in those carrying two versus one APOE*4 allele. Vascular risk factors were related to an increased effect of APOE*4 on memory decline in younger women, but a weaker effect of APOE*4 on general cognitive decline in older men. The relationship between APOE*4 carriage and memory decline was larger in older-aged Asians than Whites. In sum, APOE*4 is related to cognitive decline in men and women, although these effects are enhanced by age and carriage of two APOE*4 alleles in men, a higher numbers of vascular risk factors during the early stages of late adulthood in women, and Asian ethnicity.