JACC. Case reports · 2025
Computational Fluid Dynamics in Predicting Renal Malperfusion After Aortic Dissection Repair.
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Yang Chengwei, Shao Shujing, Leng Xiaochang, Qi Weiwei, Chen Ying, Huang Lianjun, Xu Lei, Luo Yuanming
Аннотация
BACKGROUND: Renal atrophy following aortic repair is difficult to be identified through renal function biochemical measures due to compensation. Computational fluid dynamics (CFD) analysis is a promising approach for identifying anomalies of renal blood supply, which is related to renal atrophy.
CASE SUMMARY: This study reports 3 patients who underwent renal atrophy after aortic repair during follow-up. The hemodynamics of renal arteries in each case was analyzed through employing the CFD method. The pressure ratio (PR; renal artery-to-aorta) measurements revealed significantly lower values on the atrophic side of the renal artery when comparing to the nonatrophic side.
DISCUSSION: PR is promising to serve as an early quantitative indicator, with persistent depression prior to obvious morphological atrophy. Serial CFD-based PR assessments show promise in predicting the risk of renal atrophy and facilitating earlier intervention.
TAKE-HOME MESSAGE: Patient-specific CFD simulations based on computed tomography angiography offer hemodynamic profiling to detect perfusion compromise in the preclinical phases.
CASE SUMMARY: This study reports 3 patients who underwent renal atrophy after aortic repair during follow-up. The hemodynamics of renal arteries in each case was analyzed through employing the CFD method. The pressure ratio (PR; renal artery-to-aorta) measurements revealed significantly lower values on the atrophic side of the renal artery when comparing to the nonatrophic side.
DISCUSSION: PR is promising to serve as an early quantitative indicator, with persistent depression prior to obvious morphological atrophy. Serial CFD-based PR assessments show promise in predicting the risk of renal atrophy and facilitating earlier intervention.
TAKE-HOME MESSAGE: Patient-specific CFD simulations based on computed tomography angiography offer hemodynamic profiling to detect perfusion compromise in the preclinical phases.