Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2019
Effectiveness of two physical activity programs on non-alcoholic fatty liver disease. a randomized controlled clinical trial.
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Franco Isabella, Bianco Antonella, Dìaz Maria Del Pilar, Bonfiglio Caterina, Chiloiro Marisa, Pou Sonia Alejandra, Becaria Coquet Julia, Mirizzi Antonella, Nitti Alessandro, Campanella Angelo, Leone Carla Maria, Caruso Maria Gabriella, Correale Mario, Osella Alberto Ruben
Аннотация
INTRODUCTION: To estimate the effectiveness of two physical activity programs on NAFLD.
METHODS: Participants come from a survey conducted in southern Italy. Subjects with moderate or severe NAFLD were invited to participate. After giving informed consent, they completed a questionnaire, underwent ultrasonography and anthropometric measurements. Then they were randomized an Aerobic or a Combined Exercise program and followed up for six months. The first group followed a program of moderate aerobic activity lasting 30 minutes, 5 days per week. The second group did aerobic training with the addition of muscle training involving the large muscle groups, stimulating them to make more intense efforts, for a duration of 60 minutes, at least, 3 days a week. Compliance with the programs was measured. A mixed linear model was applied to the data.
RESULTS: Compliance with Aerobic Exercise was homogeneous and increased over time. Combined Program compliance was equal to 100%. There was no significant difference in the NAFLD mean score by treatment at baseline and after six months. However, there was a significant reduction in the NAFLD mean score for treatments after six months. The NAFLD measured score was reduced by 22% in the Aerobic treatment group when confronted with the other program. In the Combined program, after 6 months, results showed to be less effective than the Aerobic Exercise in reducing the NAFLD score.
CONCLUSION: An aerobic exercise program is a realistic intervention which could be included as a part of primary prevention of several chronic diseases.
METHODS: Participants come from a survey conducted in southern Italy. Subjects with moderate or severe NAFLD were invited to participate. After giving informed consent, they completed a questionnaire, underwent ultrasonography and anthropometric measurements. Then they were randomized an Aerobic or a Combined Exercise program and followed up for six months. The first group followed a program of moderate aerobic activity lasting 30 minutes, 5 days per week. The second group did aerobic training with the addition of muscle training involving the large muscle groups, stimulating them to make more intense efforts, for a duration of 60 minutes, at least, 3 days a week. Compliance with the programs was measured. A mixed linear model was applied to the data.
RESULTS: Compliance with Aerobic Exercise was homogeneous and increased over time. Combined Program compliance was equal to 100%. There was no significant difference in the NAFLD mean score by treatment at baseline and after six months. However, there was a significant reduction in the NAFLD mean score for treatments after six months. The NAFLD measured score was reduced by 22% in the Aerobic treatment group when confronted with the other program. In the Combined program, after 6 months, results showed to be less effective than the Aerobic Exercise in reducing the NAFLD score.
CONCLUSION: An aerobic exercise program is a realistic intervention which could be included as a part of primary prevention of several chronic diseases.