Hormone research in paediatrics · 2017
Anogenital Distance in Term Newborns in Kumasi, Ghana.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Asafo-Agyei Serwah Bonsu, Ameyaw Emmanuel, Chanoine Jean-Pierre, Zacharin Margaret, Nguah Samuel Blay, Jarrett Olumide Olatokunbo
Аннотация
BACKGROUND: Anogenital distance (AGD) is a simple noninvasive measure of foetal androgen exposure. This study was done to generate normative data on AGD in Ghanaian newborns.
METHODS: AGD was measured in 644 male and 612 female term newborns; including the distance between the anterior base of the penis and the centre of the anus, the posterior base of the penis and the centre of the anus, and the posterior base of the scrotum and the centre of the anus (ASD) in males and the distance from the anus to the fourchette (AF) and from the anus to the base of the clitoris in females. Other anthropometric and parental socio-demographic indices were also documented.
RESULTS: AGD was sexually dimorphic; with a mean ± SD ASD and AF of 25.5 ± 5.1 and 13.6 ± 2.7 mm, respectively. There was a significant correlation between AGD and birth weight, birth length, and occipitofrontal circumference (p < 0.05). ASD was significantly longer (p < 0.001) in newborns (83/644; 12.9%) of mothers who had ingested herbs during pregnancy.
CONCLUSION: AGD was approximately twice as long in males compared to females and can serve as a useful indicator of androgen exposure. Measurements of AGD also need to factor in anthropometric parameters, which are important correlates of AGD.
METHODS: AGD was measured in 644 male and 612 female term newborns; including the distance between the anterior base of the penis and the centre of the anus, the posterior base of the penis and the centre of the anus, and the posterior base of the scrotum and the centre of the anus (ASD) in males and the distance from the anus to the fourchette (AF) and from the anus to the base of the clitoris in females. Other anthropometric and parental socio-demographic indices were also documented.
RESULTS: AGD was sexually dimorphic; with a mean ± SD ASD and AF of 25.5 ± 5.1 and 13.6 ± 2.7 mm, respectively. There was a significant correlation between AGD and birth weight, birth length, and occipitofrontal circumference (p < 0.05). ASD was significantly longer (p < 0.001) in newborns (83/644; 12.9%) of mothers who had ingested herbs during pregnancy.
CONCLUSION: AGD was approximately twice as long in males compared to females and can serve as a useful indicator of androgen exposure. Measurements of AGD also need to factor in anthropometric parameters, which are important correlates of AGD.