Technology, pharmacology, and clinical outcomes of sirolimus coated balloons for peripheral arterial interventions.

INTRODUCTION

Peripheral arterial intervention is a rapidly evolving field with a significant impact on an aging population.

AREAS COVERED: Treatment concepts evolve rapidly, with new therapies providing sustainable and cost-effective solutions for complex patients.

EXPERT OPINION: Metal stenting has been replaced by the 'leave-nothing-behind' approach, and plain balloon angioplasty devices have been replaced by drug-coated balloons (DCBs). While paclitaxel was initially used, sirolimus has more recently shown promising outcomes. This review article provides an overview of the technology and pharmacology behind sirolimus-coated balloons (SRL-DCB) and presents existing clinical evidence of their use.