Tropical and geographical medicine · 1987
Circadian variations of the absolute eosinophil count and serum histaminase activity in tropical pulmonary eosinophilia.
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Singh R K, Chandra R, Narang R K, Singh S K, Katiyar S K, Singh R P, Pandey H N, Joshi L D
Аннотация
Nine healthy volunteers and 25 tropical pulmonary eosinophilia (TPE) patients were used to study circadian variations of absolute eosinophil count (AEC) and serum histaminase activity (SHA). A marked circadian variation was found in AEC for healthy volunteers and TPE patients with the worst symptoms in the late evening and morning hours only; no rhythm could be detected in SHA for healthy subjects. However, TPE patients with worst symptoms in the late evening hours did exhibit a significant rhythm in SHA. Increased SHA in all TPE patients at all time-points of the 24 hour day-night cycle, irrespective of the worsening hours of symptoms in comparison to healthy controls, could be due to increased histamine production in such situations.