Preliminary findings from a retrospective comparative study on a novel hydrophobic C-loop monofocal intraocular lens.

To investigate visual outcomes and optical performance of a new non-constant aberration aspheric monofocal intraocular lens (IOL). This study included consecutive patients who underwent phacoemulsification with implantation of either the CT LUCIA® 621P intraocular lens (Carl Zeiss Meditec AG, Jena, Germany; 32 eyes, 25 patients) or the Tecnis® ZCB00 intraocular lens (Johnson & Johnson Vision, Santa Ana, CA, USA; 38 eyes, 27 patients). Monocular uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), uncorrected intermediate visual acuity (UIVA), and objective optical quality were measured 3 months after surgery. The optical bench test measured the root mean square of the modulation transfer function (MTTRMS) of each IOL at defocus levels between +1.00 D and -2.50 D at intervals of 0.25 D at varying pupil sizes (2.0-5.0 mm) in 1.0 mm steps. There was no difference in UDVA, UNVA, and objective optical quality between CT LUCIA and ZCB00 groups. On the other hand, UIVA was higher in the CT LUCIA group (0.19 ± 0.12 logMAR) compared to the ZCB00 group (0.32 ± 0.05 logMAR; p < 0.001). For all tested pupil sizes, the MTFRMS values for both CT LUCIA and ZCB00 IOLs were similar across defocus ranges from +1.00 to -0.75 D. However, the CT LUCIA IOL consistently exhibited higher MTFRMS values than the ZCB00 IOL at defocus levels from -1.25 to - 2.50 D. The CT LUCIA IOL provides comparable distance visual acuity and optical quality to ZCB00 IOL, with superior performance at intermediate distances.