Journal of affective disorders · 2025
Impact of duration of untreated illness on clinical and physical measures in early adult patients with major depressive disorder: a large-scale cross-sectional study.
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Luo Guoshuai, Gou Lei, Zhang Ke, Yang Shutong, Jiang Rui, Liu Yuanyuan, Zhou Jianan, Li Cui, Yao Cong, Li Yaxi, Zhang Xiangyang
Аннотация
BACKGROUNDS: Longer duration of untreated illness leads to worse outcomes in people with depressive disorders. However, there is a lack of research on duration of untreated illness in early adult depressed patients. This study aimed to investigate the association between the duration of duration of untreated illness and clinical and physical measures in youth with depression.
METHODS: We recruited 1289 early adult patients with major depressive disorder. Duration of untreated illness was defined as the time between the onset of depressive symptoms and the initiation of pharmacological treatment. We used bivariate and multivariate analyses to examine the association between duration of untreated illness and clinical and physical measures, adjusting for age, sex, education, and marital status.
RESULTS: Participants who had not received treatment for ≥8 months had higher odds of suicide attempts (OR: 1.77, 95 % CI: 1.15-2.74), increased thyroid-stimulating hormone (TSH) levels (OR: 2.73, 95 % CI: 1.91-3.88), and high-normal blood pressure (OR: 1.98, 95 % CI: 1.33-2.94) compared to those treated within 3 months. Each 1-month longer duration of untreated illness was associated with 5 % higher odds of suicide attempts (95 % CI: 1.02-1.08), 8 % higher odds of elevated TSH (95 % CI: 1.05-1.11), and 5 % higher odds of high-normal blood pressure (95 % CI: 1.02-1.08).
CONCLUSIONS: Our study found that a longer duration of untreated illness in depression is associated with several adverse clinical and physical correlates. These findings underscore the importance of early intervention and treatment in managing depression.
LIMITATION: The cross-sectional study design constrained causal inference.
METHODS: We recruited 1289 early adult patients with major depressive disorder. Duration of untreated illness was defined as the time between the onset of depressive symptoms and the initiation of pharmacological treatment. We used bivariate and multivariate analyses to examine the association between duration of untreated illness and clinical and physical measures, adjusting for age, sex, education, and marital status.
RESULTS: Participants who had not received treatment for ≥8 months had higher odds of suicide attempts (OR: 1.77, 95 % CI: 1.15-2.74), increased thyroid-stimulating hormone (TSH) levels (OR: 2.73, 95 % CI: 1.91-3.88), and high-normal blood pressure (OR: 1.98, 95 % CI: 1.33-2.94) compared to those treated within 3 months. Each 1-month longer duration of untreated illness was associated with 5 % higher odds of suicide attempts (95 % CI: 1.02-1.08), 8 % higher odds of elevated TSH (95 % CI: 1.05-1.11), and 5 % higher odds of high-normal blood pressure (95 % CI: 1.02-1.08).
CONCLUSIONS: Our study found that a longer duration of untreated illness in depression is associated with several adverse clinical and physical correlates. These findings underscore the importance of early intervention and treatment in managing depression.
LIMITATION: The cross-sectional study design constrained causal inference.