A case of severe ovarian hyperstimulation in a healthy oocyte donor.

OBJECTIVE

To report an unexpected case of severe ovarian hyperstimulation syndrome (OHSS) and to compare E2 levels and number of follicles to other oocyte donors.

SETTING

Private assisted reproduction technology center.

PATIENTS: Healthy oocyte donors with normal menstrual cyclicity.

INTERVENTIONS: Prophylactic and therapeutic use of human serum albumin infusions.

MAIN OUTCOME MEASURE: The clinical development of signs and symptoms of severe OHSS.

RESULTS

More than 60% of other oocyte donors had higher E2 levels and 12% had higher number of follicles without associated OHSS.

CONCLUSION

The risk of developing severe OHSS cannot be predicted accurately to be low even in the absence of "risk factors."