Reconstructing human implantation at the embryo-maternal interface.

Human embryo implantation has remained largely inaccessible to mechanistic study. Two recent Cell papers by Molè et al.1 and Li et al.2 now introduce complementary in vitro platforms that reconstruct key features of the human implantation niche, enabling interrogation of embryo-endometrium interactions and opening translational avenues to model implantation failure and test therapeutic strategies.