Cell reports · 2026
Identification of endometrial CD169+ macrophages essential for Treg cell accumulation and implantation.
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Ohki Takuto, Miyawaki Shingo, Higa Tsunaki, Yamazaki Hiroki, Okaki Hiromu, Nakajima Ryusuke, Kitamura Kai, Nakagawa Megumi G, Sanosaka Tsukasa, Tsugawa Hitoshi, Honda Kurara, Hirata Akihiro, Goto Takeshi, Handa Mika, Tokutake Katsuhiro, Saeki Sota, Yamamoto Michiro, Watanabe Kazuhiro, Maeda Sadatoshi, Takasu Masaki, Sugiura Yuki, Takiuchi Tsuyoshi, Kohyama Jun, Suematsu Makoto, Hirata Hitoshi
Аннотация
Successful pregnancy requires coordinated regulation between the innate and adaptive immune systems. Regulatory T (Treg) cells are essential for establishing maternal immune tolerance to the semi-allogeneic fetus, but the innate immune cells that modulate this process remain poorly defined. Here, we identify CD169+ macrophages in the endometrium as critical regulators of Treg cell recruitment and implantation. These CD169+ macrophages are endometrial localized, exhibit an anti-inflammatory phenotype, and secrete chemokines that attract Treg cells to the endometrium. We also identified CD169+ macrophages in the human endometrium that express chemokines involved in Treg cell recruitment. Our findings identify endometrial CD169+ macrophages as key orchestrators of Treg cell accumulation at the maternal-fetal interface, providing mechanistic insight into implantation and conceptus development.