Cell research · 2021
Coinfection with influenza A virus enhances SARS-CoV-2 infectivity.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Bai Lei, Zhao Yongliang, Dong Jiazhen, Liang Simeng, Guo Ming, Liu Xinjin, Wang Xin, Huang Zhixiang, Sun Xiaoyi, Zhang Zhen, Dong Lianghui, Liu Qianyun, Zheng Yucheng, Niu Danping, Xiang Min, Song Kun, Ye Jiajie, Zheng Wenchao, Tang Zhidong, Tang Mingliang, Zhou Yu, Shen Chao, Dai Ming, Zhou Li, Chen Yu, Yan Huan, Lan Ke, Xu Ke
Аннотация
The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, in vivo, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV. Moreover, such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses, likely due to a unique feature of IAV to elevate ACE2 expression. This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection, and thus, prevention of IAV infection is of great significance during the COVID-19 pandemic.