The COVID-19 epidemic in Madagascar: clinical description and laboratory results of the first wave, march-september 2020.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Randremanana Rindra Vatosoa, Andriamandimby Soa-Fy, Rakotondramanga Jean Marius, Razanajatovo Norosoa Harline, Mangahasimbola Reziky Tiandraza, Randriambolamanantsoa Tsiry Hasina, Ranaivoson Hafaliana Christian, Rabemananjara Harinirina Aina, Razanajatovo Iony, Razafindratsimandresy Richter, Rabarison Joelinotahiana Hasina, Brook Cara E, Rakotomanana Fanjasoa, Rabetombosoa Roger Mario, Razafimanjato Helisoa, Ahyong Vida, Raharinosy Vololoniaina, Raharimanga Vaomalala, Raharinantoanina Sandratana Jonhson, Randrianarisoa Mirella Malala, Bernardson Barivola, Randrianasolo Laurence, Randriamampionona Léa Bricette Nirina, Tato Cristina M, DeRisi Joseph L, Dussart Philippe, Vololoniaina Manuela Christophère, Randriatsarafara Fidiniaina Mamy, Randriamanantany Zely Arivelo, Heraud Jean-Michel
Аннотация
METHODS: Nasopharyngeal and/or oropharyngeal swabs were collected from travellers to Madagascar, suspected SARS-CoV-2 cases and contact of confirmed cases. Swabs were tested at the national reference laboratory using real-time RT-PCR. Data collected from patients were entered in an electronic database for subsequent statistical analysis. All distribution of laboratory-confirmed cases were mapped, and six genomes of viruses were fully sequenced.
RESULTS: Overall, 26,415 individuals were tested for SARS-CoV-2 between 18 March and 18 September 2020, of whom 21.0% (5,553/26,145) returned positive. Among laboratory-confirmed SARS-CoV-2-positive patients, the median age was 39 years (IQR: 28-52), and 56.6% (3,311/5,553) were asymptomatic at the time of sampling. The probability of testing positive increased with age with the highest adjusted odds ratio of 2.2 [95% CI: 1.9-2.5] for individuals aged 49 years and more. Viral strains sequenced belong to clades 19A, 20A and 20B indicative of several independent introduction of viruses.
CONCLUSIONS: Our study describes the first wave of the COVID-19 in Madagascar. Despite early strategies in place Madagascar could not avoid the introduction and spread of the virus. More studies are needed to estimate the true burden of disease and make public health recommendations for a better preparation to another wave.