Internal medicine (Tokyo, Japan) · 2020
Autoimmune Pulmonary Alveolar Proteinosis Complicated with Sarcoidosis: the Clinical Course and Serum Levels of Anti-granulocyte-macrophage colony-stimulating Factor Autoantibody.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Arai Toru, Kasai Takahiko, Shimizu Kazunori, Kawahara Kunimitsu, Katayama Kanako, Sugimoto Chikatoshi, Hirose Masaki, Okamoto Hiroyuki, Tachibana Kazunobu, Akira Masanori, Inoue Yoshikazu
Аннотация
Autoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction due to anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody. We experienced 2 cases of APAP complicated with sarcoidosis in a 42-year-old woman and a 51-year-old man (age at the sarcoidosis diagnosis). APAP preceded sarcoidosis in the woman, and both diseases were diagnosed simultaneously in the man. Sarcoidosis lesions were observed in the lung, skin, and eyes, and the pathological findings of APAP were not marked at the diagnosis of sarcoidosis in either case. Low-grade positive serum anti-GM-CSF autoantibody was suspected to be correlated with the occurrence of sarcoidosis and resolution of APAP.