Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
Reproductive Factors Do Not Influence Survival with Ovarian Cancer.
СтатьяПоддержка правительства СШАПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Phung Minh Tung, Alimujiang Aliya, Berchuck Andrew, Anton-Culver Hoda, Schildkraut Joellen M, Bandera Elisa V, Chang-Claude Jenny, Chase Anne, Doherty Jennifer Anne, Grout Bronwyn, Goodman Marc T, Hanley Gillian E, Lee Alice W, McKinnon Deurloo Cindy, Menon Usha, Modugno Francesmary, Pharoah Paul D P, Pike Malcolm C, Richardson Jean, Risch Harvey A, Sieh Weiva, Terry Kathryn L, Webb Penelope M, Wentzensen Nicolas, Wu Anna H, Pearce Celeste Leigh
Аннотация
BACKGROUND: Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes.
METHODS: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype.
RESULTS: During the mean follow-up of 6.34 years (SD = 4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among patients with ovarian cancer overall or by histotype.
CONCLUSIONS: This study found no association between reproductive factors and survival after an ovarian cancer diagnosis.
IMPACT: Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.
METHODS: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype.
RESULTS: During the mean follow-up of 6.34 years (SD = 4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among patients with ovarian cancer overall or by histotype.
CONCLUSIONS: This study found no association between reproductive factors and survival after an ovarian cancer diagnosis.
IMPACT: Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.