Annali dell'Istituto superiore di sanita · 2025
EpiWEAT: a new digital assessment tool for epigenetic studies.
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Giustini Marco, Carannante Anna, Bacocco Duilio Luca, Caredda Emanuele, Magliocchetti Patrizia, Cersosimo Giuseppina, Foschino Barbaro Maria Grazia, Piccinini Andrea, Cremonesi Paolo, Gaudi Simona
Аннотация
INTRODUCTION: Intimate partner violence (IPV) profoundly impacts women's health, increasing the risk of chronic and non-communicable diseases. Recent findings underscore the promise of epigenetic indicators to uncover the enduring effects of trauma on the human genome, especially concerning stress-related conditions such as post-traumatic stress disorder (PTSD).
OBJECTIVES: To evaluate the lasting health impacts of violence against women, developing a digital tool specifically structured to consolidate crucial details about the contexts of violence, the relationship between victim and perpetrator, and health outcomes.
METHODS: A Microsoft Forms-based questionnaire was developed, organized into nine sections addressing socio-personal information, external conditions of violence, health statuses, and psychological evaluations, incorporating PTSD assessment via the International Trauma Questionnaire and depression measurement through the Center for epidemiologic studies depression scale revised (CESD-R) module. Data is securely archived, and participation includes optional consent for epigenetic analysis through blood samples.
CONCLUSIONS: The assessment tool presents a thorough tool for gathering information on IPV, evaluating health outcomes, and identifying PTSD and depression in survivors. It also aids in the collection of biological specimens for epigenetic exploration. This instrument could enhance intervention strategies and contribute to precision medicine methodologies, facilitating early detection of chronic health risks in women who have experienced violence.
OBJECTIVES: To evaluate the lasting health impacts of violence against women, developing a digital tool specifically structured to consolidate crucial details about the contexts of violence, the relationship between victim and perpetrator, and health outcomes.
METHODS: A Microsoft Forms-based questionnaire was developed, organized into nine sections addressing socio-personal information, external conditions of violence, health statuses, and psychological evaluations, incorporating PTSD assessment via the International Trauma Questionnaire and depression measurement through the Center for epidemiologic studies depression scale revised (CESD-R) module. Data is securely archived, and participation includes optional consent for epigenetic analysis through blood samples.
CONCLUSIONS: The assessment tool presents a thorough tool for gathering information on IPV, evaluating health outcomes, and identifying PTSD and depression in survivors. It also aids in the collection of biological specimens for epigenetic exploration. This instrument could enhance intervention strategies and contribute to precision medicine methodologies, facilitating early detection of chronic health risks in women who have experienced violence.