American journal of ophthalmology · 1997
Treatment of fungal corneal ulcers with amphotericin B ointment.
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Hirose H, Terasaki H, Awaya S, Yasuma T
Аннотация
PURPOSE: To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment.
METHODS: Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, respectively. By antifungal susceptibility testing, amphotericin B was shown to have the lowest minimal inhibitory concentration.
RESULT: Topical administration of amphotericin B ointment resulted in dramatic improvement in fungal corneal ulcers.
CONCLUSIONS: Antifungal susceptibility tests may aid with selection of antifungal agents. Amphotericin B ointment is one of the promising therapies for keratomycosis caused by antimycotic-resistant fungi.
METHODS: Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, respectively. By antifungal susceptibility testing, amphotericin B was shown to have the lowest minimal inhibitory concentration.
RESULT: Topical administration of amphotericin B ointment resulted in dramatic improvement in fungal corneal ulcers.
CONCLUSIONS: Antifungal susceptibility tests may aid with selection of antifungal agents. Amphotericin B ointment is one of the promising therapies for keratomycosis caused by antimycotic-resistant fungi.