Yan ke xue bao = Eye science · 1996
Changes in local immune functions in Mooren's ulcer.
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Wang Z, Chen J, Zheng H
Аннотация
PURPOSE: To the investigate changes in local immune functions of the cornea and the adjacent conjunctiva, and their roles in the mechanism of the disease.
METHOD: The cornea and adjacent bulbar conjunctiva taken from 14 patients with Mooren's ulcer were stained immunohistochemically for CD3, CD4, CD8, HLA-DR, CD1 and CD25.
RESULT: An aberrant expression of HLA-DR antigen by a large number of kerato-conjunctival epithelial cells and keratocytes in the corneal stroma was found. The CD4+/CD8+ ratio is significantly higher than normal control.
CONCLUSION: The aberrant expression of MHC-II antigen in the resident cells at the peripheral cornea and the adjacent conjunctiva, along with a raised local TH/Ts ratio leading to an excessive autoimmune reactivity is possibly the direct cause of Mooren's ulcer.
METHOD: The cornea and adjacent bulbar conjunctiva taken from 14 patients with Mooren's ulcer were stained immunohistochemically for CD3, CD4, CD8, HLA-DR, CD1 and CD25.
RESULT: An aberrant expression of HLA-DR antigen by a large number of kerato-conjunctival epithelial cells and keratocytes in the corneal stroma was found. The CD4+/CD8+ ratio is significantly higher than normal control.
CONCLUSION: The aberrant expression of MHC-II antigen in the resident cells at the peripheral cornea and the adjacent conjunctiva, along with a raised local TH/Ts ratio leading to an excessive autoimmune reactivity is possibly the direct cause of Mooren's ulcer.