Biofouling · 2025
Exploring quinazoline-derived copper(I) complex coated intravaginal ring against vulvovaginal candidiasis causing Candida species.
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Krishnan Dhesiga, Aruna Senthil Kumar Sudaarsan, Jothipandiyan Sowndarya, Yamuna Devi Venkatesan, Suresh Devarajan, Nithyanand Paramasivam
Аннотация
Vulvovaginal candidiasis (VVC) is especially prevalent among intrauterine device (IUD) and intravaginal ring (IVR) users. Candida albicans is the leading causative agent of VVC followed by Candida glabrata. Ascribed to the increased drug resistance by Candida spp. to the currently available drugs, this study has focused on the novel quinazoline-derived copper(I) complexes as anti-candida agents. As a novel approach, a vaginal ring was coated with the best quinazoline-derived copper(I) complex, and biofilm disruption ability was evaluated. The coated vaginal ring eradicated 70% of preformed biofilms and also inhibited the hyphal transition of Candida albicans in a simulated vaginal fluid (SVF). The overall study validates the anti-biofilm and anti-virulent properties of the metal complex-coated vaginal ring using various microscopic studies.