Subungual Leiyomyoma Presenting as Erythronychia: Case Report and Review of the Literature.

We report a rare case of leiomyoma of the fingernail in a 59-year-old woman. She presented with red discoloration, lifting, and distal splitting of her left 2nd fingernail for several months. She reported sensitivity at baseline which became more painful in the cold. Histopathology sections from the nail matrix biopsy specimen showed a dermal proliferation of bland appearing spindle shaped cells with elongated, blunt ended nuclei (SMA and caldesmon positive), arranged in fascicles, which is typical of leiomyomas. Interestingly, our patient had a history of uterine leiomyoma, requiring hysterectomy. To our knowledge, this case is the first report in which a subungual leiomyoma is associated with another leiomyoma in the same patient. J Drugs Dermatol. 2019;18(5):465-467.