Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC).
СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pischon Tobias, Lahmann Petra H, Boeing Heiner, Tjønneland Anne, Halkjaer Jytte, Overvad Kim, Klipstein-Grobusch Kerstin, Linseisen Jakob, Becker Nikolaus, Trichopoulou Antonia, Benetou Vassiliki, Trichopoulos Dimitrios, Sieri Sabina, Palli Domenico, Tumino Rosario, Vineis Paolo, Panico Salvatore, Monninkhof Evelyn, Peeters Petra H M, Bueno-de-Mesquita H Bas, Büchner Frederike L, Ljungberg Börje, Hallmans Göran, Berglund Göran, Gonzalez Carlos Alberto, Dorronsoro Miren, Gurrea Aurelio Barricarte, Navarro Carmen, Martinez Carmen, Quirós J Ramón, Roddam Andrew, Allen Naomi, Bingham Sheila, Khaw Kay-Tee, Kaaks Rudolf, Norat Teresa, Slimani Nadia, Riboli Elio
Аннотация
Previous studies suggest that obesity is related to increased risk of renal cell carcinoma (RCC); however, only a few studies report on measures of central vs. peripheral adiposity. We examined the association between anthropometric measures, including waist and hip circumference and RCC risk among 348,550 men and women free of cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC). During 6.0 years of follow-up we identified 287 incident cases of RCC. Relative risks were calculated using Cox regression, stratified by age and study center and adjusted for smoking status, education, alcohol consumption, physical activity, menopausal status, and hormone replacement therapy use. Among women, an increased risk of RCC was conferred by body weight (relative risk [RR] in highest vs. lowest quintile = 2.13; 95% confidence interval [CI] = 1.16-3.90; p-trend = 0.003), body mass index (BMI) (RR = 2.25; 95% CI = 1.14-4.44; p-trend = 0.009), and waist (RR = 1.67; 95% CI = 0.94-2.98; p-trend = 0.003) and hip circumference (RR = 2.30; 95% CI = 1.22-4.34; p-trend = 0.01); however, waist and hip circumference were no longer significant after controlling for body weight. Among men, hip circumference (RR = 0.44; 95% CI = 0.20-0.98; p-trend = 0.03) was related significantly to decreased RCC risk only after accounting for body weight. Height was not related significantly to RCC risk. Our findings suggest that obesity is related to increased risk of RCC irrespective of fat distribution among women, whereas low hip circumference is related to increased RCC risk among men. Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases.