Vaccines · 2025
Transient Hepatitis B Surface Antigenemia Following Immunization with the Adjuvanted Hepatitis B Vaccine Fendrix®.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Fernández-Espinilla Virginia, Ardura-Agudín Paula, Sánchez-Carmona Daniel Leonardo, Sanz-Ballesteros Sandra, Cobo-Campuzano Kenia Piedad, Hernán-García Cristina, Castrodeza-Sanz José Javier, Prada-García María Del Camino
Аннотация
BACKGROUND: Serological screening for HBV is standard in hemodialysis, and vaccination is recommended for non-immune patients.
OBJECTIVE: To determine the cause of positive HBsAg detected shortly after vaccination.
METHODS: We conducted a retrospective study in a tertiary hemodialysis unit. Patients with HBsAg reactivity after receiving the adjuvanted HBV vaccine (Fendrix®) were followed with serial serology until HBsAg clearance.
RESULTS: Forty-four patients were monitored; seven (15.9%) tested HBsAg-positive 1-7 days post-vaccination, with no evidence of acute hepatitis, prior HBV infection, transplantation, or chronic immunosuppression. Six cleared HBsAg on repeat testing; one remained positive until day 19, with HBsAg as the only marker.
CONCLUSIONS: Vaccine-related transient HBsAg antigenemia can occur shortly after immunization. Recognizing this phenomenon and timing routine serology appropriately can prevent misinterpretation and unnecessary workups in CKD patients.
OBJECTIVE: To determine the cause of positive HBsAg detected shortly after vaccination.
METHODS: We conducted a retrospective study in a tertiary hemodialysis unit. Patients with HBsAg reactivity after receiving the adjuvanted HBV vaccine (Fendrix®) were followed with serial serology until HBsAg clearance.
RESULTS: Forty-four patients were monitored; seven (15.9%) tested HBsAg-positive 1-7 days post-vaccination, with no evidence of acute hepatitis, prior HBV infection, transplantation, or chronic immunosuppression. Six cleared HBsAg on repeat testing; one remained positive until day 19, with HBsAg as the only marker.
CONCLUSIONS: Vaccine-related transient HBsAg antigenemia can occur shortly after immunization. Recognizing this phenomenon and timing routine serology appropriately can prevent misinterpretation and unnecessary workups in CKD patients.