Novel Approach to Tracking Mutant Huntingtin in Biosamples.

Although the established causative agent in Huntington's disease (HD) is a mutation in a single gene encoding huntingtin protein, the pathogenic cascade preceding neuronal death and disease onset is both incompletely understood and clinically undetectable. A new article published in Molecular Cell explores mutant huntingtin (mHtt) aggregate seeding activity as an early pathogenesis-tracking parameter with potential biomarker quality.