Anemia risk and mitigation strategies in type 2 diabetic patients: The role of novel antidiabetic agents.

Anemia is a common yet often overlooked complication in patients with type 2 diabetes mellitus (T2DM), particularly those with chronic kidney disease. It significantly impacts patients' quality of life, cardiovascular health, and treatment outcomes. Despite its high prevalence, current clinical guidelines lack specific recommendations for anemia prevention and management in T2DM, especially in the context of newer antidiabetic therapies. This review explores the potential of emerging antidiabetic medications, such as sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), and combined GLP-1-RA/GIP to mitigate anemia risk. Early detection and management of anemia in T2DM patients are crucial for improving glycemic control, reducing cardiovascular morbidity, and enhancing overall treatment outcomes. This review underscores the need for further research to better understand the mechanisms by which these novel therapies influence anemia risk and to integrate these findings into clinical practice.