[Determination of 27 fragrances in cosmetics and perfume raw materials by gas chromatography-mass spectrometry].

A chromatographic separation method for 27 fragrances in cosmetics and perfume raw materials was developed using gas chromatography-mass spectrometry (GC-MS). A weak polar capillary column and electron impact ion source were used in the GC-MS analysis, with methanol as the extraction solvent. The limits of detection were 1.2, 15, and 15 mg/kg for musk xylene, hydroxycitronellal, and hydroxyisohexyl-3-cyclohexene carboxaldehyde, respectively, and 3.0 mg/kg for the other 24 fragrances. The calibration line of the 27 fragrances presented a good relationship with correlation coefficients ≥ 0.996. At three spiked concentration levels, the relative standard deviations were <10% and the spiked recoveries were in the ranges of 73.3%-76.1% for musk xylene and 81.5%-118% for the other fragrances. Based on these determinations, one or more fragrance ingredients were detected in 69 perfume raw materials and cosmetics, the labels of which indicated that they contained fragrances. This method can be used to determine 27 fragrances in cosmetic and perfume raw materials.