Primary Intestinal NK/T-cell Lymphoma Masquerading as Crohn's Disease: A Report of Two Cases.

Extranodal NK/T-cell lymphoma (ENKTL) most commonly affects the upper aerodigestive tract. Primary intestinal NK/T-cell lymphoma is extremely rare and poses a formidable challenge for both the gastroenterologists and pathologists. We herein report two cases of ENKTL. On histopathological and immunohistochemical examination of the resected specimens, a final diagnosis of primary intestinal NK/T-cell lymphoma was made. Due to significant overlap in clinical, endoscopic, and histopathological findings, this entity is often misdiagnosed as Crohn's disease. Multiple endoscopic biopsies with the use of an elaborate immunohistochemical panel can help in diagnosis at an early stage, thereby improving the management and prognosis.