Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer.
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Kyrø Cecilie, Olsen Anja, Landberg Rikard, Skeie Guri, Loft Steffen, Åman Per, Leenders Max, Dik Vincent K, Siersema Peter D, Pischon Tobias, Christensen Jane, Overvad Kim, Boutron-Ruault Marie-Christine, Fagherazzi Guy, Cottet Vanessa, Kühn Tilman, Chang-Claude Jenny, Boeing Heiner, Trichopoulou Antonia, Bamia Christina, Trichopoulos Dimitrios, Palli Domenico, Krogh Vittorio, Tumino Rosario, Vineis Paolo, Panico Salvatore, Peeters Petra H, Weiderpass Elisabete, Bakken Toril, Åsli Lene Angell, Argüelles Marcial, Jakszyn Paula, Sánchez María-José, Amiano Pilar, Huerta José María, Barricarte Aurelio, Ljuslinder Ingrid, Palmqvist Richard, Khaw Kay-Tee, Wareham Nick, Key Timothy J, Travis Ruth C, Ferrari Pietro, Freisling Heinz, Jenab Mazda, Gunter Marc J, Murphy Neil, Riboli Eilo, Tjønneland Anne, Bueno-de-Mesquita H B as
Аннотация
METHODS: The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.
RESULTS: High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).
CONCLUSIONS: High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.