Leukemia & lymphoma · 2019
Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting.
СтатьяResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод в очереди
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Cohen Jeffrey I, Iwatsuki Keiji, Ko Young-Hyeh, Kimura Hiroshi, Manoli Irini, Ohshima Koichi, Pittaluga Stefania, Quintanilla-Martinez Leticia, Jaffe Elaine S
Аннотация
Epstein-Barr virus (EBV) normally infects B cells, but in some persons the virus infects T or NK cells. Infection of B cells can result in infectious mononucleosis, and the virus is associated with several B cell malignancies including Hodgkin lymphoma, Burkitt lymphoma, and diffuse large B cell lymphoma. Infection of T or NK cells with EBV is associated with extranodal NK/T cell lymphoma, aggressive NK-cell leukemia, systemic EBV-associated T-cell lymphoma, and chronic active EBV disease, which in some cases can include hydroa vacciniforme-like lymphoproliferative disease and severe mosquito bite allergy. While NK and T cell lymphoproliferative disease is more common in Asia and Latin America, increasing numbers of cases are being reported from the United States and Europe. This review focuses on classification, clinical findings, pathogenesis, and recent genetic advances in NK and T cell lymphoproliferative diseases associated with EBV.