Медицинская библиотека · Clinical laboratory · 2019

Fever with Positive EBV IgM Antibody Combined Multiple Subcutaneous Nodules on Lower Extremities and Cervical Lymphadenopathy Masquerading as Infectious Mononucleosis Proven as Subcutaneous Panniculitis-like T-cell Lymphoma by Subcutaneous Nodule Biopsy Consultation: a Case Report and Literature Review.

Ge Yan L, Zhang Qian, Wang Meng H, Zhang Hao L, Rana Md A, Li Wen Q, Chen Yi, Liu Cong H, Zhang Shuang, Hao Chen, Zhang Ci, Zhu Xiao Y, Li Li Q, Fu Ai S

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Аннотация

BACKGROUND

We report a case that presented as fever with positive Epstein-Barr Virus (EBV) IgM antibody combined with subcutaneous nodules on lower extremities and cervical lymphadenopathy firstly misdiagnosed as infectious mononucleosis, which was proven as subcutaneous panniculitis-like T-cell lymphoma by subcutaneous nodule biopsies.

METHODS

Appropriate serum and bacteriological laboratory tests were carried out for the cause of fever. An ultrasound and subcutaneous nodule biopsies were performed.

RESULTS

EBV IgM antibody was positive. An ultrasound revealed multiple subcutaneous nodules, which were prone to be lipoma on lower extremities and cervical lymphadenopathy. Subcutaneous nodule biopsies were firstly misdiagnosed as lipoma, while pathology consultation for the subcutaneous nodule biopsies diagnosed subcutaneous panniculitis-like T-cell lymphoma.

CONCLUSIONS

When patients have persistent fever with positive EBV IgM antibody combined other system involvements, especially lymphadenopathy and multiple subcutaneous nodules, it should differentiate lymphoma from infectious diseases.

Для цитирования: Ge Yan L, Zhang Qian, Wang Meng H, Zhang Hao L, Rana Md A, Li Wen Q, Chen Yi, Liu Cong H, Zhang Shuang, Hao Chen, Zhang Ci, Zhu Xiao Y, Li Li Q, Fu Ai S. Fever with Positive EBV IgM Antibody Combined Multiple Subcutaneous Nodules on Lower Extremities and Cervical Lymphadenopathy Masquerading as Infectious Mononucleosis Proven as Subcutaneous Panniculitis-like T-cell Lymphoma by Subcutaneous Nodule Biopsy Consultation: a Case Report and Literature Review.. Clinical laboratory. 2019. DOI: 10.7754/clin.lab.2019.181255.

Предметные рубрики MeSH

Adult Antibodies, Viral Biopsy Diagnosis, Differential Female Fever Herpesvirus 4, Human Humans Immunoglobulin M Infectious Mononucleosis Lower Extremity Lymphadenopathy Lymphoma, T-Cell Neck Panniculitis Referral and Consultation Subcutaneous Tissue

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