Association between multi inflammatory index and heart failure in patients with coronary heart disease: a RCSCD-TCM study in China.

BACKGROUND

Anti-inflammatory therapy could become a new target for the treatment of heart failure (HF), and multi inflammatory index (MII) is a new index composed of an inflammatory index. Then, the relationship between MII and HF is not completely clear.

OBJECTIVES

The aim of this study was to investigate the association of MII and HF in coronary heart disease (CHD) patients.

METHODS

In a cohort of 17,937 patients with CHD, 6386 had HF. Logistic regression analysis was used to analyze the relationship between the MII and HF in CHD patients. The relationship between MII and HF was also assessed according to sex, blood pressure, and blood glucose.

RESULTS

Compared with T1 of MII, MII-1 had the highest T3 (OR: 1.33; 95% CI: 1.23-1.45; P < 0.001), and MII-3 had the lowest T3 (OR: 1.25; 95% CI: 1.16-1.36; P < 0.001). In both sexes, MII-1 was more associated with HF than MII-2 and MII-3. In binary logistic regression analysis, when MII was treated as a continuous variable, MII-1 was significantly associated with HF risk in CHD patients with hypertension (OR: 1.06; 95% CI: 1.02-1.10; P = 0.002) and in CHD patients with diabetes (OR: 1.04; 95% CI: 1.00-1.08; P = 0.040). All MII were associated with HF. The MII-1 proved to be superior.

CONCLUSION

In patients with CHD, the association between the MII and HF was stronger in female than in male. There was a association between MII and risk of HF in with CHD patients after multivariate adjustment.