Head & neck · 2019
Clinical management and outcomes of lacrimal sac squamous cell carcinoma.
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Song Xinmao, Wang Shengzi, Wang Jie, Wang Weifang, Wang Shuyi, Yang Gang, Li Ji, Zhu Yi, Chen Fu, Zhu Wenjia
Аннотация
BACKGROUND: To investigate the management and outcomes of patients with lacrimal sac squamous cell carcinoma (SCC).
METHODS: This retrospective study examined 69 lacrimal sac SCC cases treated at our hospital between 1992 and 2017. The potential risk factors for prognosis, a new staging method, treatment outcomes, and complications were investigated.
RESULTS: The 5-year overall survival (OS) and progression-free survival (PFS) were 87.6 ± 4.8% and 76.3 ± 6.4%, respectively. Positive lymph node was associated with worse OS and PFS. We divided lacrimal sac SCC into four clinical stages, with significant differences in OS (P = .026) and PFS (P = .042) among each stage. Definitive radiotherapy was equivalent to surgery plus radiotherapy in 26.1% (18/69) of cases, and the incidence of complications was not higher.
CONCLUSIONS: Lymph node status was a key factor in determining outcomes. Our staging method could effectively classify tumor stage and predict prognosis, which can contribute to optimizing treatment regimes. Radiotherapy played an important role in treatment.
METHODS: This retrospective study examined 69 lacrimal sac SCC cases treated at our hospital between 1992 and 2017. The potential risk factors for prognosis, a new staging method, treatment outcomes, and complications were investigated.
RESULTS: The 5-year overall survival (OS) and progression-free survival (PFS) were 87.6 ± 4.8% and 76.3 ± 6.4%, respectively. Positive lymph node was associated with worse OS and PFS. We divided lacrimal sac SCC into four clinical stages, with significant differences in OS (P = .026) and PFS (P = .042) among each stage. Definitive radiotherapy was equivalent to surgery plus radiotherapy in 26.1% (18/69) of cases, and the incidence of complications was not higher.
CONCLUSIONS: Lymph node status was a key factor in determining outcomes. Our staging method could effectively classify tumor stage and predict prognosis, which can contribute to optimizing treatment regimes. Radiotherapy played an important role in treatment.
Предметные рубрики MeSH
AdultAgedCarcinoma, Squamous CellChemotherapy, AdjuvantCohort StudiesCombined Modality TherapyDisease ManagementDisease-Free SurvivalEye NeoplasmsFemaleHumansKaplan-Meier EstimateLogistic ModelsMagnetic Resonance ImagingMaleMiddle AgedNasolacrimal DuctNeoplasm InvasivenessNeoplasm StagingRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTaiwanTreatment Outcome