Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2013
A rare but severe complication of filgrastim in a healthy donor: splenic rupture.
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Akyol Gulsah, Pala Cigdem, Yildirim Afra, Keklika Muzaffer, Demir Koray, Dortdudak Sumeyra, Sivgin Serdar, Kaynar Leylagul, Esera Bulent, Unal Ali, Cetin Mustafa
Аннотация
BACKGROUND: Granulocyte-colony stimulating factor (G-CSF) is widely administered to donors who provide peripheral blood stem cells (PBSCs) for individuals who undergo hematopoietic stem cell transplants. G-CSF administration is associated with a small but definite risks of serious adverse events like splenic rupture.
CASE STUDY: In this case, we report a 40 year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16×6 cm.
RESULTS: She was followed conservatively. One month later the CT scan signs of rupture disappeared.
CONCLUSION: We must pay attention to this rare but serious adverse event during filgrastim use.
CASE STUDY: In this case, we report a 40 year old women, a healthy donor for her sister who has aplastic anemia, who had sharp left upper abdominal pain on the forth mobilization day. The diagnosis at CT scan was splenic rupture; irregular intrasplenic low-attenuation areas consistent with ruptured spleen and perisplenic high density fluid. Her bidimensional spleen size was 16×6 cm.
RESULTS: She was followed conservatively. One month later the CT scan signs of rupture disappeared.
CONCLUSION: We must pay attention to this rare but serious adverse event during filgrastim use.