Use of exosomes as adjuvant therapy in the reconstruction of traumatic eyelid wounds: A case report.

Traumatic eyelid wounds with tissue loss pose a reconstructive challenge due to the risk of inflammation-driven fibrosis and functional impairment. Adipose-derived stem cell-derived exosomes have demonstrated regenerative and antifibrotic effects in cutaneous wound-healing models. We report a case of high-energy periocular trauma in which standard oculoplastic reconstruction was supplemented with staged topical and microneedling-assisted exosome therapy. Accelerated epithelialization, favorable scar modulation, and preservation of eyelid contour and function were observed without adverse events. This case supports the feasibility of exosome-based therapy as an adjunct in complex eyelid wound reconstruction.