Recurrence of disease after liver transplantation.

Over the past decade, we have seen an increased number of patients living more than 20 years with their liver grafts. In turn, we are gaining more experience with recurrence of the original disease. Disease recurrence can be divided into 4 main groups: (1) malignant disease, (2) viral disease, (3) autoimmune diseases like primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSO), and finally (4) researched lifestyle that caused the original disease, eg, obesity causing nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), or alcoholic liver disease (ALD). This overview reports follow up, diagnosis, and treatment of recurrences.