Journal of ethnopharmacology · 2026
Beyond HbS polymerization inhibition: Antioxidant and anti-hemolytic actions of two varieties of Vigna sesquipedalis (L.) F.Agcaoili in sickle cell disease.
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Anorue Eleazar Chukwuemeka, Sheneni Victor Duniya
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Polymerization is a major pathological feature of sickle cell disease (SCD). Although conventional therapies reduce disease severity, their use is limited by adverse effects, high cost, and poor accessibility in resource-limited settings. Vigna sesquipedalis (L.) F.Agcaoili, a leguminous plant widely cultivated and consumed in tropical regions of Africa and Asia, is traditionally used in folklore medicine for blood nourishment and general health. The plant is rich in flavonoids and polyphenols with reported antioxidant and potential anti-sickling properties, but its role in inhibition of haemoglobin S polymerization and membrane stabilization remains poorly explored.
AIM OF THE STUDY: This study evaluated the polymerization inhibition, anti-hemolytic, and antioxidant properties of brown and white V. sesquipedalis extracts in sickle cell disease.
MATERIALS AND METHODS: Red blood cells obtained from SCD patients were treated with brown and white V. sesquipedalis extracts at concentrations of 500 and 1000 μg mL-1 and compared with untreated and standard drug controls. Hemoglobin polymerization, Fe2+/Fe3+ ratio, methemoglobin formation, hemolysis, oxidative stress markers, and some biochemical indices were assessed. Functional groups in the most active extract were identified using Fourier Transform Infrared (FTIR) spectroscopy.
RESULTS: Both extracts inhibited polymerization of oxy-HbS, increased the Fe2+/Fe3+ ratio, reduced methemoglobin formation and hemolysis, and suppressed lipid peroxidation. The brown V. sesquipedalis extract consistently showed superior efficacy compared to the white variety.
CONCLUSION: Vigna sesquipedalis, particularly the brown variety, exhibits significant polymerization inhibition effect, antioxidant, and anti-hemolytic effects in SCD, supporting its ethnopharmacological relevance and early-stage preclinical evidence as an anti-sickling agent.
AIM OF THE STUDY: This study evaluated the polymerization inhibition, anti-hemolytic, and antioxidant properties of brown and white V. sesquipedalis extracts in sickle cell disease.
MATERIALS AND METHODS: Red blood cells obtained from SCD patients were treated with brown and white V. sesquipedalis extracts at concentrations of 500 and 1000 μg mL-1 and compared with untreated and standard drug controls. Hemoglobin polymerization, Fe2+/Fe3+ ratio, methemoglobin formation, hemolysis, oxidative stress markers, and some biochemical indices were assessed. Functional groups in the most active extract were identified using Fourier Transform Infrared (FTIR) spectroscopy.
RESULTS: Both extracts inhibited polymerization of oxy-HbS, increased the Fe2+/Fe3+ ratio, reduced methemoglobin formation and hemolysis, and suppressed lipid peroxidation. The brown V. sesquipedalis extract consistently showed superior efficacy compared to the white variety.
CONCLUSION: Vigna sesquipedalis, particularly the brown variety, exhibits significant polymerization inhibition effect, antioxidant, and anti-hemolytic effects in SCD, supporting its ethnopharmacological relevance and early-stage preclinical evidence as an anti-sickling agent.