Identification of Mrm2 as a key regulator in mitochondrial dysfunction during radiation-induced intestinal injury.

BACKGROUND

Radiation-induced intestinal injury (RIII) is a serious complication of radiotherapy and is closely associated with mitochondrial dysfunction, but the underlying mechanism remains unclear.

METHODS

Mitochondria‑related differentially expressed genes (DEGs) were identified using online databases in an RIII model. Histopathological staining analysis was performed to evaluate injury severity. The expression of Mrm2 was examined in vivo after irradiation.

RESULTS

The core functional modules of the identified DEGs included mitochondrial‑coding genes and apoptosis‑related genes. Histopathological analysis showed that RIII aggravated significantly in a dose‑ and time‑dependent manner. Notably, Mrm2 was continuously upregulated after irradiation in vivo.

CONCLUSION

Mrm2 may serve as a key regulatory factor mediating mitochondrial dysfunction in radiation‑induced intestinal injury.