The frequency of 7S rheumatoid factors and 22S complexes in human sera with positive latex tests for rheumatoid factor.

In sera with positive latex tests for rheumatoid factors, the immunoglobulin class of the antiglobulins is influenced by the quantity of immunoglobulins present in the serum. Sera with 7S antiglobulins have high levels of IgG and IgA immunoglobulins. 22S complexes tend to be found in sera with high levels of IgM immunoglobulins. These findings suggest that the occurrence of antiglobulins and 22S complexes may be influenced by the hypergammaglobulinemia.