Asian journal of psychiatry · 2025
Resting-state functional connectivity of the default mode network subsystems as a potential biomarker for delusions in patients with first-episode drug-naïve schizophrenia.
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Guo Qihui, Zhu Rongrong, Gao Jianliang, Wang Anzhen, Fan Ruomei, Wang Liusu, Wang Dongmei, Zhang Xiangyang
Аннотация
OBJECTIVES: Previous studies have indicated a close association between delusions and the default mode network (DMN). This study aimed to explore the relationship between delusions and resting-state functional connectivity (rsFC) of subsystem-specific DMN in patients with first-episode drug-naïve schizophrenia (FESCZ).
METHODS: This study recruited 79 FESCZ patients. The severity of delusions was assessed using the PANSS P1 item, with a score of ≥ 4 defining the clear presence of delusions. Seed-to-seed rsFC matrices were calculated between 11 DMN seed regions, which belong to three subsystems: the core, the dorsomedial prefrontal cortex (dMPFC), and the medial temporal lobe (MTL).
RESULTS: Compared with patients without clear delusions, patients with clear delusions exhibited hyperconnectivity between the core and the MTL subsystems. The severity of delusions was positively correlated with the core-MTL rsFC strength. Post-hoc analyses revealed that specific rsFC edges (rsFC between posterior cingulate cortex and retrosplenial cortex, as well as between posterior cingulate cortex and posterior inferior parietal lobule) were significantly correlated with the severity of delusions.
CONCLUSIONS: The DMN core-MTL rsFC strength is associated with delusions in FESCZ patients, which may serve as a potential biomarker for the severity of delusions and offer novel neurobiological insights for delusions treatment.
METHODS: This study recruited 79 FESCZ patients. The severity of delusions was assessed using the PANSS P1 item, with a score of ≥ 4 defining the clear presence of delusions. Seed-to-seed rsFC matrices were calculated between 11 DMN seed regions, which belong to three subsystems: the core, the dorsomedial prefrontal cortex (dMPFC), and the medial temporal lobe (MTL).
RESULTS: Compared with patients without clear delusions, patients with clear delusions exhibited hyperconnectivity between the core and the MTL subsystems. The severity of delusions was positively correlated with the core-MTL rsFC strength. Post-hoc analyses revealed that specific rsFC edges (rsFC between posterior cingulate cortex and retrosplenial cortex, as well as between posterior cingulate cortex and posterior inferior parietal lobule) were significantly correlated with the severity of delusions.
CONCLUSIONS: The DMN core-MTL rsFC strength is associated with delusions in FESCZ patients, which may serve as a potential biomarker for the severity of delusions and offer novel neurobiological insights for delusions treatment.